Pituitary Adenylate Cyclase Activating Polypeptide
نویسندگان
چکیده
منابع مشابه
Pituitary adenylate cyclase activating polypeptide and migraine
Pituitary adenylate cyclase activating peptide (PACAP) is found in human trigeminocervical complex and can trigger migraine. PACAP levels were measured using a sensitive radioimmunoassay. Stimulation of the superior sagittal sinus (SSS) in cat elevated PACAP levels in cranial blood. Patients with moderate or severe migraine headache had elevated PACAP in the external jugular vein during headach...
متن کاملPituitary adenylate cyclase-activating polypeptide and adrenomedullary function.
PITUITARY ADENYLATE CYCLASE-activating polypeptide (PACAP) is an ancestral molecule for a superfamily of 11 hormones and hormone-like substances that have a secretin-containing core in common. These include PACAP, glucagon, glucagon-like peptide-1 and -2, growth hormone-releasing hormone, VIP, peptide histidine methionine, secretin, and glucose-dependent insulinotropic polypeptide (see extensiv...
متن کاملAdenylate Cyclase-Activating Polypeptide in Rodents
14 Abstract Administration of the long form (38 amino acids) 15 of pituitary adenylate cyclase-activating polypeptide 16 (PACAP38) into the central nervous system causes hyperther17 mia, suggesting that PACAP38 plays a role in the regulation of 18 deep body temperature (Tb). In this study, we investigated the 19 thermoregulatory role of PACAP38 in details. First, we in20 fused PACAP38 intracere...
متن کاملInteractions of ovarian steroids with pituitary adenylate cyclase-activating polypeptide and GnRH in anterior pituitary cells.
Pituitary adenylate cyclase-activating polypeptide (PACAP) releases LH and FSH from anterior pituitary cells. Although this effect is relatively weak, it has a strong sensitizing action on GnRH-induced gonadotropin secretion. Here we investigated the possibility that ovarian steroids, which are well-known modulators of LH secretion, interact with PACAP and GnRH in pituitary gonadotrophs. Rat pi...
متن کاملPituitary adenylate cyclase-activating polypeptide (PACAP) stimulates adenylate cyclase and promotes proliferation of mouse primordial germ cells.
During migration and for about 2 days after their arrival in the gonadal ridges, primordial germ cells (the embryonic precursors of gametes of the adult animal) proliferate actively. Certain growth factors, such as stem cell factor and leukemia inhibitory factor, seem to be essential for survival, proliferation and possibly differentiation of mouse primordial germ cell in vivo and/or in vitro. ...
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ژورنال
عنوان ژورنال: The American Journal of Pathology
سال: 2010
ISSN: 0002-9440
DOI: 10.2353/ajpath.2010.090941